Going forward, researchers aim to test this technology in humans. They also found that repeated treatments with the L-SOMA dosed with insulin induced the same results, suggesting it may be effective to give multiple, subsequent doses using L-SOMA. They then collected blood samples from each of the animals and found that the L-SOMA pill delivered medications at comparable levels to those given with an injection. To evaluate the pill's efficacy, researchers tested the L-SOMA devices in pigs, dosing each one with one of four treatments, including insulin, epinephrine, adalimumab (a monoclonal antibody used to treat rheumatoid arthritis, Crohn's disease and other autoimmune diseases) and a semaglutide-like GLP-1 analog (an anti-diabetic medication). This innovation expands upon the developed technology by enabling the device to work with liquid medications that need to be absorbed more quickly or are challenging to formulate as solids. Traverso and colleagues based the L-SOMA on their initial invention, the SOMA, which injects solid medications but does not work with liquid drugs. After the L-SOMA delivers the drug, the needle retracts back into the capsule. The pill contains a retractable needle that injects the treatment directly into tissue within the stomach. The researchers designed the L-SOMA so that it can be loaded with up to 4 mg doses of a desired medication. "Our group focuses on developing systems that make it easier for patients to receive their medications." Giovanni Traverso, MB, BChir, Ph.D., of the Division of Gastroenterology, Hepatology and Endoscopy at the Brigham and the Department of Mechanical Engineering at MIT. ![]() If we can make it easier for patients to receive their medication, we can help maximize drug adherence or compliance," said C. "We recognize today that pills are the preferred route of drug administration, not only for patients, but also for health care providers.
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